九州大学大学院医学研究院
衛生・公衆衛生学分野

Sato S, Arima H, Hirakawa Y, Heeley E, Delcourt C, Beer R, Li Y, Zhang J, Jüettler E, Wang J, Lavados PM, Robinson T, Lindley RI, Chalmers J, Anderson CS; INTERACT Investigators

The speed of ultraearly hematoma growth in acute intracerebral hemorrhage.

Neurology 　83: 2232-2238, 2014

Zoungas S, Chalmers J, Neal B, Billot L, Li Q, Hirakawa Y, Arima H, Monaghan H, Joshi R, Colagiuri S, Cooper ME, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Lisheng L, Mancia G, Marre M, Matthews DR, Mogensen CE, Perkovic V, Poulter N, Rodgers A, Williams B, MacMahon S, Patel A, Woodward M; ADVANCE-ON Collaborative Group

Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.

N Engl J Med 　371: 1392-1406, 2014

Kaizu S, Kishimoto H, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai T, Kikuchi Y, Idewaki Y, Hirakawa Y, Nakamura U, Kitazono T

Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.

PLoS One 　9: e98768, 2014

Hirakawa Y, Arima H, Zoungas S, Ninomiya T, Cooper M, Hamet P, Mancia G, Poulter N, Harrap S, Woodward M, Chalmers J

Impact of visit-to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE trial.

Diabetes Care 　37: 2359-2365, 2014

Manning L, Hirakawa Y, Arima H, Wang X, Chalmers J, Wang J, Lindley R, Heeley E, Delcourt C, Neal B, Lavados P, Davis SM, Tzourio C, Huang Y, Stapf C, Woodward M, Rothwell PM, Robinson TG, Anderson CS; INTERACT2 investigators

Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

Lancet Neurol 　13: 364-373, 2014

Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T

U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry.

Metabolism 　63: 484-491, 2014

Chalmers J, Arima H, Woodward M, Mancia G, Poulter N, Hirakawa Y, Zoungas S, Patel A, Williams B, Harrap S

Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial.

Hypertension　 63: 259-264, 2014

The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects)(Hisayama Study: Arima H, Iida M, Kiyohara Y)

Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants.

Lancet　383: 970-983, 2014

Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y, Nakabeppu Y

Altered expression of diabetes-related genes in alzheimer's disease brains: the Hisayama Study.

Cereb Cortex 　24: 2476-2488, 2014

Kakudate N, Muramatsu T, Endoh M, Satomura K, Koseki T, Sato Y, Ito K, Ogasawara T, Nakamura S, Kishimoto E, Kashiwazaki H, Yamashita Y, Uchiyama K, Nishihara T, Kiyohara Y, Kakinoki Y

Factors associated with dry mouth in dependent Japanese elderly.

Gerodontology 　31: 11-18, 2014

Takeshita T, Matsuo K, Furuta M, Shibata Y, Fukami K, Shimazaki Y, Akifusa S, Han DH, Kim HD, Yokoyama T, Ninomiya T, Kiyohara Y, Yamashita Y

Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults.

Sci Rep 　4: 6990, 2014

Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS).

Metabolism 　63: 1093-1103, 2014

Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (Doi Y, Hata J, Kiyohara Y, Ninomiya T)

Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.

Lancet Diabetes Endocrinol 　2: 634-647, 2014

Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension( Kiyohara Y, Doi Y)

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014).

Hypertens Res 　37: 253-390, 2014

Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Ninomiya T, Hata J)

Glycated hemoglobin measurement and prediction of cardiovascular disease.

JAMA 　311: 1225-1233, 2014

Asayama K, Satoh M, Murakami Y, Ohkubo T, Nagasawa SY, Tsuji I, Nakayama T, Okayama A, Miura K, Imai Y, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group (Kiyohara Y)

Cardiovascular risk with and without antihypertensive drug treatment in the Japanese general population: participant-level meta-analysis.

Hypertension 　63: 1189-1197, 2014

Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators

Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.

J Neurol Sci 　340: 75-79, 2014

Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H; NIPPON DATA80 Research Group (Kiyohara Y)

High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: a 24-year follow-up of Japanese general population.

J Cardiol 　64: 218-224, 2014

Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.

Arterioscler Thromb Vasc Biol 　34: 790-800, 2014

Hamasaki H, Honda H, Suzuki SO, Hokama M, Kiyohara Y, Nakabeppu Y, Iwaki T

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.

Neuropathology 　34: 284-290, 2014

Pennells L, Kaptoge S, White IR, Thompson SG, Wood AM; Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Doi Y, Ninomiya T)

Assessing risk prediction models using individual participant data from multiple studies.

Am J Epidemiol 　179: 621-632, 2014

Inohara T, Kohsaka S, Okamura T, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Murakami Y, Ohkubo T, Miura K, Okayama A, Ueshima H; NIPPON DATA 80/90 Research Group (Kiyohara Y)

Cumulative impact of axial, structural, and repolarization ECG findings on long-term cardiovascular mortality among healthy individuals in Japan: National Integrated Project for Prospective Observation of Non-Communicable Disease and its Trends in the Aged, 1980 and 1990.

Eur J Prev Cardiol 　21: 1501-1508, 2014

Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y

Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study.

J Epidemiol Community Health　68: 663-668, 2014

Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y

A low ankle brachial index is associated with an increased risk of cardiovascular disease: the Hisayama study.

J Atheroscler Thromb　21: 966-973, 2014

Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y

Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.

J Am Geriatr Soc　62: 1224-1230, 2014

Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yosida T, Kiyohara Y, Sato S, Tsuzaki k, Takahashi K, Kuzuya H, the Japan Diabetes Prevention Program(JDPP)Reserch Group

Effect of baseline HbA1c level on the development of diabetes by lifestyle intervention in primary healthcare settings: insights from subanalysis of the Japan Diabetes Prevention Program

BMJ Open Diabetes Res Care　2: e000003, 2014

Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M

Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population: the Hisayama Study.

PLoS One 　9: e90984, 2014

Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y

Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study．

J Diabetes Invest　5: 162-169, 2014

Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T

The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort．

PLoS One 　9: e92549, 2014

Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.

Cardiovasc Diabetol 　13: 45, 2014

Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y

Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.

Atherosclerosis　233: 343-348, 2014

Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y

Serum 1,25-dihydroxyvitamin D and the development of kidney dysfunction in a Japanese community: the Hisayama Study.

Circ J　 78: 732-737, 2014

Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y

Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community: the Hisayama Study.

Circ J 　78: 403-409, 2014