Study NameJapan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

Overview

Japan Prospective Studies Collaboration for Aging and Dementia

Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study is a collaborative prospective cohort study of approximately 10,000 elderly people from 8 newly-established community-based dementia cohort studies in Japan, in which the data is prospectively collected by using the pre-specified standardized protocol. The purpose of this study is to evaluate quantitatively environmental and genomic risk factors for dementia in Japanese and to establish effective preventive strategies for dementia, in order to realize healthy aging society.
In this study, the definitions of collected data and the diagnostic procedures of dementia have been pre-specified across the cohort studies in 2015 before starting the baseline survey. Approximately 10,000 community-dwelling individuals aged 65 years or older at 8 sites of Japan will be recruited in the baseline survey from 2016 to 2018, and followed up to detect incident cases of dementia for at least 5 years. In the baseline survey, the following data has been collected: lifestyle information (smoking habits, alcohol intakes, diet, physical activity, etc.), medical history, physical examination, blood test, and brain magnetic resonance imaging (MRI). Frozen samples of serum and plasma (-80℃) have been also stored.
This study has been funded by the research and development grants for dementia, Japan Agency for Medical Research and Development (AMED) since 2015.

Research Design

Locations of
Collaborating Organizations

(Planned Sample Size (N) ≒10,000 individuals)

Organization

Principal investigator Toshiharu Ninomiya.
Steering Committee Toshiharu Ninomiya, Shigeyuki Nakaji, Tetsuya Maeda, Moeko Shinohara, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi.
Study Secretariats Mao Shibata, Jun Hata, Tomoyuki Ohara, Yoichiro Hirakawa, Takanori Honda, Akane Mihara, Naoki Hirabayashi, Yoshihiko Furuta, Taro Nakazawa.
Endpoint Adjudication Committee Tomoyuki Ohara, Yoshihiro Kokubo, Jun Hata.
Data Quality Control Committee Toshiharu Ninomiya (Clinical data), Kazuhiro Uchida (Diet data), Yasuyuki Taki (Imaging data), Koji Yonemoto (Statistics), Hisako Yoshida (Statistics).
Research Ethic Support Committee Kaori Muto.
Genome and omics analysis Yukihide Momozawa, Masato Akiyama, Chikashi Terao, Katsuyuki Yugi.
Advisory board Yutaka Kiyohara (Advisor for epidemiology), Michiaki Kubo (Advisor for Genomic study), Manabu Ikeda (Advisor for dementia and depression), Shigenobu Kanba (Advisor for dementia and depression)

Research Group

Name Position and Affiliation Name Position and Affiliation
Toshiharu Ninomiya Professor, Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Tomoyuki Ohara Lecturer, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
Shigeyuki Nakaji Professor, Department of Social Medicine, Graduate School of Medicine, Hirosaki University Yoshihiro Kokubo Director, Department of Preventive Medicine, National Cerebral and Cardiovascular Center
Tetsuya Maeda Professor, Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University Jun Hata Associate Professor, Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
Moeko Shinohara Associate Professor, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences Kazuhiro Uchida Associate Professor, Department of Health Promotion, School of Health and Nutrition Sciences, Nakamura-Gakuen University
Masaru Mimura Professor, Department of Neuropsychiatry, Keio University School of Medicine Yasuyuki Taki Professor, Co-Deputy Director, Smart-Aging Research Center, Tohoku University
Kenji Nakashima Honorary director, National Hospital Organization, Matsue Medical Center Kaori Muto Professor, The Institute of Medical Science, The University of Tokyo, Department of Public Policy
Takaaki Mori Assistant Professor & Lecturer, Department of Neuropsychiatry, Neuroscience Ehime University Graduate School of Medicine Yukihide Momozawa Team leader, Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
Minoru Takebayashi

Professor, Department of Neuropsychiatry, Faculty of Life Science Kumamoto University

Masato Akiyama Associate professor, Department of Pathology and Imaging Science, Kyushu University Graduate School of Medical Sciences
Research Collaborators:
Yutaka Kiyohara(Chief Executive Director, Hisayama Research Institute for Lifestyle Diseases)
Michiaki Kubo(Visiting fellow, Hisayama Research Institute for Lifestyle Diseases)
Manabu Ikeda(Professor, Department of Psychiatry, Osaka University Medical School)
Shigenobu Kanba(Professor Emeritus, Kyushu University)
Masahito Yamada(Professor, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences)
Koji Yonemoto(Professor, Division of Biostatistics, School of Health Sciences, Faculty of Medicine, University of the Ryukyus)
Hisako Yoshida(Associate Professor, Department of Medical Statistics, Osaka City University Graduate School of Medicine)
Shuzo Kumagai(Director, Kumagai Institute of Health Policy / Professor Emeritus, Kyushu University)
Chikashi Terao(Team leader, Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences)
Katsuyuki Yugi(Team Leader, Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences)

Organization Chart for JPSC-AD