• Sato S, Arima H, Hirakawa Y, Heeley E, Delcourt C, Beer R, Li Y, Zhang J, Jüettler E, Wang J, Lavados PM, Robinson T, Lindley RI, Chalmers J, Anderson CS; INTERACT Investigators

    The speed of ultraearly hematoma growth in acute intracerebral hemorrhage.

    Neurology  83: 2232-2238, 2014 pubmed

  • Zoungas S, Chalmers J, Neal B, Billot L, Li Q, Hirakawa Y, Arima H, Monaghan H, Joshi R, Colagiuri S, Cooper ME, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Lisheng L, Mancia G, Marre M, Matthews DR, Mogensen CE, Perkovic V, Poulter N, Rodgers A, Williams B, MacMahon S, Patel A, Woodward M; ADVANCE-ON Collaborative Group

    Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.

    N Engl J Med  371: 1392-1406, 2014 pubmed

  • Kaizu S, Kishimoto H, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai T, Kikuchi Y, Idewaki Y, Hirakawa Y, Nakamura U, Kitazono T

    Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.

    PLoS One  9: e98768, 2014 pubmed

  • Hirakawa Y, Arima H, Zoungas S, Ninomiya T, Cooper M, Hamet P, Mancia G, Poulter N, Harrap S, Woodward M, Chalmers J

    Impact of visit-to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE trial.

    Diabetes Care  37: 2359-2365, 2014 pubmed

  • Manning L, Hirakawa Y, Arima H, Wang X, Chalmers J, Wang J, Lindley R, Heeley E, Delcourt C, Neal B, Lavados P, Davis SM, Tzourio C, Huang Y, Stapf C, Woodward M, Rothwell PM, Robinson TG, Anderson CS; INTERACT2 investigators

    Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

    Lancet Neurol  13: 364-373, 2014 pubmed

  • Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T

    U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry.

    Metabolism  63: 484-491, 2014 pubmed

  • Chalmers J, Arima H, Woodward M, Mancia G, Poulter N, Hirakawa Y, Zoungas S, Patel A, Williams B, Harrap S

    Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial.

    Hypertension  63: 259-264, 2014 pubmed

  • The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects)(Hisayama Study: Arima H, Iida M, Kiyohara Y)

    Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants.

    Lancet 383: 970-983, 2014 pubmed

  • Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y, Nakabeppu Y

    Altered expression of diabetes-related genes in alzheimer's disease brains: the Hisayama Study.

    Cereb Cortex  24: 2476-2488, 2014 pubmed

  • Kakudate N, Muramatsu T, Endoh M, Satomura K, Koseki T, Sato Y, Ito K, Ogasawara T, Nakamura S, Kishimoto E, Kashiwazaki H, Yamashita Y, Uchiyama K, Nishihara T, Kiyohara Y, Kakinoki Y

    Factors associated with dry mouth in dependent Japanese elderly.

    Gerodontology  31: 11-18, 2014 pubmed

  • Takeshita T, Matsuo K, Furuta M, Shibata Y, Fukami K, Shimazaki Y, Akifusa S, Han DH, Kim HD, Yokoyama T, Ninomiya T, Kiyohara Y, Yamashita Y

    Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults.

    Sci Rep  4: 6990, 2014 pubmed

  • Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

    Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS).

    Metabolism  63: 1093-1103, 2014 pubmed

  • Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (Doi Y, Hata J, Kiyohara Y, Ninomiya T)

    Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.

    Lancet Diabetes Endocrinol  2: 634-647, 2014 pubmed

  • Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension( Kiyohara Y, Doi Y)

    The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014).

    Hypertens Res  37: 253-390, 2014 pubmed

  • Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Ninomiya T, Hata J)

    Glycated hemoglobin measurement and prediction of cardiovascular disease.

    JAMA  311: 1225-1233, 2014 pubmed

  • Asayama K, Satoh M, Murakami Y, Ohkubo T, Nagasawa SY, Tsuji I, Nakayama T, Okayama A, Miura K, Imai Y, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group (Kiyohara Y)

    Cardiovascular risk with and without antihypertensive drug treatment in the Japanese general population: participant-level meta-analysis.

    Hypertension  63: 1189-1197, 2014 pubmed

  • Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators

    Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.

    J Neurol Sci  340: 75-79, 2014 pubmed

  • Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H; NIPPON DATA80 Research Group (Kiyohara Y)

    High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: a 24-year follow-up of Japanese general population.

    J Cardiol  64: 218-224, 2014 pubmed

  • Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y

    Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.

    Arterioscler Thromb Vasc Biol  34: 790-800, 2014 pubmed

  • Hamasaki H, Honda H, Suzuki SO, Hokama M, Kiyohara Y, Nakabeppu Y, Iwaki T

    Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.

    Neuropathology  34: 284-290, 2014 pubmed

  • Pennells L, Kaptoge S, White IR, Thompson SG, Wood AM; Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Doi Y, Ninomiya T)

    Assessing risk prediction models using individual participant data from multiple studies.

    Am J Epidemiol  179: 621-632, 2014 pubmed

  • Inohara T, Kohsaka S, Okamura T, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Murakami Y, Ohkubo T, Miura K, Okayama A, Ueshima H; NIPPON DATA 80/90 Research Group (Kiyohara Y)

    Cumulative impact of axial, structural, and repolarization ECG findings on long-term cardiovascular mortality among healthy individuals in Japan: National Integrated Project for Prospective Observation of Non-Communicable Disease and its Trends in the Aged, 1980 and 1990.

    Eur J Prev Cardiol  21: 1501-1508, 2014 pubmed

  • Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y

    Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study.

    J Epidemiol Community Health 68: 663-668, 2014 pubmed

  • Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y

    A low ankle brachial index is associated with an increased risk of cardiovascular disease: the Hisayama study.

    J Atheroscler Thromb 21: 966-973, 2014 pubmed

  • Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y

    Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.

    J Am Geriatr Soc 62: 1224-1230, 2014 pubmed

  • Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yosida T, Kiyohara Y, Sato S, Tsuzaki k, Takahashi K, Kuzuya H, the Japan Diabetes Prevention Program(JDPP)Reserch Group

    Effect of baseline HbA1c level on the development of diabetes by lifestyle intervention in primary healthcare settings: insights from subanalysis of the Japan Diabetes Prevention Program

    BMJ Open Diabetes Res Care 2: e000003, 2014 pubmed

  • Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population: the Hisayama Study.

    PLoS One  9: e90984, 2014 pubmed

  • Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y

    Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study.

    J Diabetes Invest 5: 162-169, 2014 pubmed

  • Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T

    The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort.

    PLoS One  9: e92549, 2014 pubmed

  • Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

    Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.

    Cardiovasc Diabetol  13: 45, 2014 pubmed

  • Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y

    Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.

    Atherosclerosis 233: 343-348, 2014 pubmed

  • Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y

    Serum 1,25-dihydroxyvitamin D and the development of kidney dysfunction in a Japanese community: the Hisayama Study.

    Circ J  78: 732-737, 2014 pubmed

  • Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y

    Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community: the Hisayama Study.

    Circ J  78: 403-409, 2014 pubmed

九州大学大学院 医学研究院





九州大学大学院 医学研究院


〒812-8582 福岡市東区馬出3-1-1
TEL:092-642-6151 FAX:092-642-4854 Mail:info_eph@hisayamalife.or.jp