九州大学大学院医学研究院
衛生・公衆衛生学分野

Tomiyama H, Ohkuma T, Ninomiya T, Nakano H, Matsumoto C, Avolio A, Kohro T, Higashi Y, Maruhashi T, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Chikamori T, Yamashina A

Brachial-ankle pulse wave velocity versus its stiffness index β-transformed value as risk marker for cardiovascular disease.

J Am Heart Assoc　8: e013004, 2019

Sasaki T, Tsuboi N, Okabayashi Y, Haruhara K, Kanzaki G, Koike K, Kobayashi A, Yamamoto I, Takahashi S, Ninomiya T, Shimizu A, Rule AD, Bertram JF, Yokoo T

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology.

Sci Rep　9: 14400, 2019

Jardine MJ, Li N, Ninomiya T, Feng X, Zhang J, Shi J, Zhang Y, Zhang R, Zhang J, Hao J, Perkovic V, Heerspink HL, Wu Y, Yan LL, Neal B

Dietary sodium reduction reduces albuminuria: a cluster randomized trial.

J Ren Nutr　29: 276-284, 2019

WHO CVD Risk Chart Working Group (Hisayama: Ninomiya T, Hata J, Hirakawa Y)

World health organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.

Lancet Glob Health 　7: e1332-e1345, 2019

Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

Periodontitis is associated with chronic obstructive pulmonary disease.

J Dent Res　98: 534-540, 2019

Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators

Poor glycemic control and posterior circulation ischemic stroke.

Neurol Clin Pract 　9: 129-139, 2019

Fujiwara K, Yasuda M, Hata J, Yoshida D, Kishimoto H, Hashimoto S, Yoshitomi T, Ninomiya T, Sonoda KH

Long-term regular exercise and intraocular pressure: the Hisayama Study.

Graefes Arch Clin Exp Ophthalmol　257: 2461-2469, 2019

Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T

Serum lipopolysaccharide-binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the Hisayama Study.

J Am Heart Assoc　8: e013628, 2019

Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T

Serum elaidic acid concentration and risk of dementia: the Hisayama Study.

Neurology　93: e2053-e2064, 2019

Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T

Reduced estimated GFR and cardiac remodeling: a population-based autopsy study.

Am J Kidney Dis　74: 373-381, 2019

Fujiwara K, Yasuda M, Hata J, Hirakawa Y, Hashimoto S, Ueda E, Iwase A, Araie M, Yoshitomi T, Ninomiya T, Sonoda KH

Glucose tolerance levels and circumpapillary retinal nerve fiber layer thickness in a general Japanese population: the Hisayama Study.

Am J Ophthalmol　205: 140-146, 2019

Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Hata J, Hirakawa Y, Ninomiya T, Sonoda KH

Association between axial length and myopic maculopathy: the Hisayama Study.

Ophthalmol Retina　3: 867-873, 2019

Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T

Association between serum β-Alanine and risk of dementia.

Am J Epidemiol　188: 1637-1645, 2019

Kageyama S, Takeshita T, Takeuchi K, Asakawa M, Matsumi R, Furuta M, Shibata Y, Nagai K, Ikebe M, Morita M, Masuda M, Toh Y, Kiyohara Y, Ninomiya T, Yamashita Y

Characteristics of the salivary microbiota in patients with various digestive tract cancers.

Front Microbiol　10: 1780-1789, 2019

Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T

NT-proBNP and risk of dementia in a general Japanese elderly population: the Hisayama Study.

J Am Heart Assoc　8: e011652, 2019

Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T

Serum ethylamine levels as an indicator of L-theanine consumption and the risk of type 2 diabetes in a general Japanese population: the Hisayama Study.

Diabetes Care　42: 1234-1240, 2019

Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH

Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: the Hisayama Study.

Invest Ophthalmol Vis Sci　60: 2781-2786, 2019

Hamasaki H, Honda H, Suzuki SO, Shijo M, Ohara T, Hatabe Y, Okamoto T, Ninomiya T, Iwaki T

Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: the Hisayama study.

Alzheimers Dement (Amst)　11: 415-423, 2019

NCD Risk Factor Collaboration (NCD-RisC)(Hata J, Ninomiya T)

Rising rural body-mass index is the main driver of the global obesity epidemic in adults.

Nature　569: 260-264, 2019

Marklund M, Wu JHY, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, Chen TA, de Oliveira Otto MC, Hirakawa Y, Eriksen HH, Kröger J, Laguzzi F, Lankinen M, Murphy RA, Prem K, Samieri C, Virtanen J, Wood AC, Wong K, Yang WS, Zhou X, Baylin A, Boer JMA, Brouwer IA, Campos H, Chaves PHM, Chien KL, de Faire U, Djoussé L, Eiriksdottir G, El-Abbadi N, Forouhi NG, Michael Gaziano J, Geleijnse JM, Gigante B, Giles G, Guallar E, Gudnason V, Harris T, Harris WS, Helmer C, Hellenius ML, Hodge A, Hu FB, Jacques PF, Jansson JH, Kalsbeek A, Khaw KT, Koh WP, Laakso M, Leander K, Lin HJ, Lind L, Luben R, Luo J, McKnight B, Mursu J, Ninomiya T, Overvad K, Psaty BM, Rimm E, Schulze MB, Siscovick D, Skjelbo Nielsen M, Smith AV, Steffen BT, Steffen L, Sun Q, Sundström J, Tsai MY, Tunstall-Pedoe H, Uusitupa MIJ, van Dam RM, Veenstra J, Monique Verschuren WM, Wareham N, Willett W, Woodward M, Yuan JM, Micha R, Lemaitre RN, Mozaffarian D, Risérus U; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)

Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality.

Circulation　139: 2422-2436, 2019

Toyama T, Neuen BL, Jun M, Ohkuma T, Neal B, Jardine MJ, Heerspink HL, Wong MG, Ninomiya T, Wada T, Perkovic V

Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis.

Diabetes Obes Metab　21: 1237-1250, 2019

Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T

Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988–2012: the Hisayama Study.

Diabetol Int　10: 198-205, 2019

Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T

Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study.

Am J Clin Nutr　109: 1664-1671, 2019

Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T

Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study.

J Diabetes Investig　10: 809-816, 2019

Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T

Prevalence of adult epilepsy in a general Japanese population: the Hisayama study.

Epilepsia Open　4: 182-186, 2019

Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y

Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study.

BMJ Open　9: e023673, 2019

Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium (Ninomiya T)

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Neurology　92: e944-e950, 2019

Tanaka S, Ninomiya T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Nakano T, Tsuruya K, Kitazono

Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study.

Sci Rep　9: 1043-1050, 2019

Emerging Risk Factors Collaboration (Ninomiya T, Doi Y, Kiyohara Y)

Cardiovascular risk factors associated with venous thromboembolism.

JAMA Cardiol　4: 163-173, 2019

Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; Collaborative Group for J-BAVELs

Steno-stiffness approach for cardiovascular disease risk assessment in primary prevention.

Hypertension　73: 508-513, 2019

Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O'Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M

Moyamoya disease susceptibility variant RNF213 p.R4810K increases the risk of ischemic stroke attributable to large-artery atherosclerosis.

Circulation　139: 295-298, 2019

Nakamura M, Ojima T, Nagahata T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K; NIPPON DATA2010 Research Group

Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010.

Environ Health Prev Med　24: 1-9, 2019

Salam, Atkins, Sundström, Hirakawa, Ettehad, Emdin, Neal, Woodward, Chalmers, Berge, Yusuf, Rahimi , Rodgers; Blood Pressure Lowering Treatment Trialists’ Collaboration

Effects of blood pressure lowering on cardiovascular events, in the context of regression to the mean: a systematic review of randomized trials.

J Hypertens　37: 16-23, 2019

Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S

Longitudinal changes of physical activity and sedentary time in the middle-aged and older Japanese population: the Hisayama Study.

J Phys Act Health　16: 165-171, 2019

Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T

Serum soluble triggering receptor expressed on myeloid cells 2 as a biomarker for incident dementia: the Hisayama Study.

Ann Neurol　85: 47-58, 2019

Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T

Association between genetic risk and development of type 2 diabetes in a general Japanese population: The Hisayama Study.

J Clin Endocrinol Metab　2019