• NCD Risk Factor Collaboration (NCD-RisC)(Ninomiya T, Hata J)

    Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.

    Int J Epidemiol 47: 872-883, 2018 pubmed

  • MEGASTROKE Consortium (Ninomiya T, Hata J)

    GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

    Nat Commun 9: 5141, 2018 pubmed

  • Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T

    Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.

    Hum Genet 137: 521-533, 2018 pubmed

  • Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

    Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi.

    Brain Pathol 28: 58-71, 2018 pubmed

  • Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators

    Insulin resistance and clinical outcomes after acute ischemic stroke.

    Neurology 90: e1470-e1477, 2018 pubmed

  • Lo C, Toyama T, Wang Y, Lin J, Hirakawa Y, Jun M, Cass A, Hawley CM, Pilmore H, Badve SV, Perkovic V, Zoungas S

    Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.

    Cochrane Database Syst Rev 9: CD011798, 2018 pubmed

  • Okabayashi Y, Tsuboi N, Amano H, Miyazaki Y, Kawamura T, Ogura M, Narita I, Ninomiya T, Yokoyama H, Yokoo T

    Distribution of nephrologists and regional variation in the clinical severity of IgA nephropathy at biopsy diagnosis in Japan: a cross-sectional study.

    BMJ Open 8: e024317, 2018 pubmed

  • VARIABLE BRAIN consortium( Ninomiya T, Ohara T, Oishi E)

    The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol.

    Syst Rev 7: 163, 2018 pubmed

  • Oshima M, Toyama T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Hara A, Makino H, Wada T; Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan

    Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes.

    PLoS One 13: e0201535, 2018 pubmed

  • Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI)

    Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis.

    Atherosclerosis 275: 141-148, 2018 pubmed

  • MEGASTROKE Consortium( Ninomiya T, Hata J)

    Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

    Nat Genet 50: 524-537, 2018 pubmed

  • Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group (Ninomiya T, Kiyohara Y)

    Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study.

    J Clin Lipidol 12: 674-684, 2018 pubmed

  • Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K

    Secular trends in the incidence of end-stage renal disease and its risk factors in Japanese patients with immunoglobulin A nephropathy.

    Nephrol Dial Transplant 33: 963-971, 2018 pubmed

  • Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T

    Association between daily sleep duration and risk of dementia and mortality in a Japanese community.

    J Am Geriatr Soc 66: 1911-1918, 2018 pubmed

  • Fujiwara K, Yasuda M, Hata J, Oshima Y, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Ninomiya T, Sonoda KH

    Prevalence and risk factors for polypoidal choroidal vasculopathy in a general Japanese population: the Hisayama Study.

    Semin Ophthalmol 33: 813-819, 2018 pubmed

  • Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

    Periodontal status and lung function decline in the community: the Hisayama Study.

    Sci Rep 8: 13354, 2018 pubmed

  • Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y

    Tongue microbiota and oral health status in community-dwelling elderly adults.

    mSphere 3: e00332-18, 2018 pubmed

  • Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study.

    Atherosclerosis 279: 38-44, 2018 pubmed

  • Tanaka M, Honda T, Yamakage H, Hata J, Yoshida D, Hirakawa Y, Shibata M, Inoue T, Kusakabe T, Satoh-Asahara N, Ninomiya T

    A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama Study.

    Diabetes Res Clin Pract 146: 225-232, 2018 pubmed

  • Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community.

    Neurology: Clinical Practice 8: 223-231, 2018 pubmed

  • Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T

    Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study.

    J Affect Disord 237: 73-79, 2018 pubmed

  • Murakami K, Ohkubo T, Nakamura M, Ninomiya T, Ojima T, Shirai K, Nagahata T, Kadota A, Okuda N, Nishi N, Okamura T, Ueshima H, Okayama A, Miura K

    Socioeconomic Inequalities in Oral Health among Middle-Aged and Elderly Japanese: NIPPON DATA2010.

    J Epidemiol 28(Supplement_III): S59-S65, 2018 pubmed

  • Nagahata T, Nakamura M, Ojima T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K

    Relationships among Food Group Intakes, Household Expenditure, and Education Attainment in a General Japanese Population: NIPPON DATA2010.

    J Epidemiol 28(Supplement_III): S23-S28, 2018 pubmed

  • Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; collaborative group for J-BAVEL-IAD (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies to Examine the Significance of Inter-Arm Blood Pressure Difference)

    Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis.

    Hypertension 71: 1030-1038, 2018 pubmed

  • Peters SAE, Wang X, Lam TH, Kim HC, Ho S, Ninomiya T, Knuiman M, Vaartjes I, Bots ML, Woodward M; Asia Pacific Cohort Studies Collaboration (Hisayama: Ninomiya T, Hata J, Hirakawa Y)

    Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration.

    BMJ Open 8: e019335, 2018 pubmed

  • Chen T, Kishimoto H, Honda T, Hata J, Yoshida D, Mukai N, Shibata M, Ninomiya T, Kumagai S

    Patterns and Levels of Sedentary Behavior and Physical Activity in a General Japanese Population: The Hisayama Study.

    J Epidemiol 28: 260-265, 2018 pubmed

  • Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

    Development and validation of a risk assessment tool for gastric cancer in a general Japanese population.

    Gastric Cancer 21: 383-390, 2018 pubmed

  • Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study.

    Atherosclerosis 273: 84-90, 2018 pubmed

  • Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study.

    J Am Heart Assoc 7: e006693, 2018 pubmed

九州大学大学院 医学研究院





九州大学大学院 医学研究院


〒812-8582 福岡市東区馬出3-1-1
TEL:092-642-6151 FAX:092-642-4854 Mail:info_eph@hisayamalife.or.jp