• Natriuretic Peptides Studies Collaboration (Ninomiya T)

    Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis.

    Lancet Diabetes Endocrinol 4: 840-849, 2016 pubmed

  • Woodward M, Hirakawa Y, Kengne AP, Matthews DR, Zoungas S, Patel A, Poulter N, Grobbee R, Cooper M, Jardine M, Chalmers J; ADVANCE Collaborative Group

    Prediction of 10-year vascular risk in patients with diabetes: the AD-ON risk score.

    Diabetes Obes Metab  18: 289-294, 2016 pubmed

  • Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Colagiuri S, Hamet P, Harrap S, Poulter N, Matthews DR, Marre M, Chalmers J

    Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study.

    Cardiovasc Diabetol 15: 129, 2016 pubmed

  • Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Colagiuri S, Hamet P, Harrap S, Poulter N, Matthews DR, Marre M, Chalmers J

    Microvascular and macrovascular disease and risk for major peripheral arterial disease in patients with type 2 diabetes.

    Diabetes Care 39: 1796-1803, 2016 pubmed

  • Yu S, Arima H, Bertmar C, Hirakawa Y, Priglinger M, Evans K, Krause M

    Depression but not anxiety predicts recurrent cerebrovascular events.

    Acta Neurol Scand 134: 29-34, 2016 pubmed

  • Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

    Combination of Helicobacter pylori Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study.

    J Epidemiol  26: 629-636, 2016 pubmed

  • Tsukuya G, Samukawa T, Matsumoto K, Fukuyama S, Kumamoto T, Uchida A, Koriyama C, Ninomiya T, Inoue H

    Comparison of the COPD Population Screener and International Primary Care Airway Group questionnaires in a general Japanese population: the Hisayama study.

    Int J Chron Obstruct Pulmon Dis   11: 1903-1909, 2016 pubmed

  • Liyanage T, Ninomiya T, Wang A, Neal B, Jun M, Wong MG, Jardine M, Hillis GS, Perkovic V

    Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis.

    PLoS One  11: e0159252, 2016 pubmed

  • Hamasaki H, Honda H, Okamoto T, Koyama S, Suzuki SO, Ohara T, Ninomiya T, Kiyohara Y, Iwaki T

    Recent increases in hippocampal tau pathology in the aging Japanese population: the Hisayama Study.

    J Alzheimers Dis  55: 613-624, 2016 pubmed

  • Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, Sakumi K, Torisu T, Chida K, Sueishi K, Kubo M, Hata J, Kitazono T, Kiyohara Y, Nakabeppu Y

    PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.

    Genes Cells  21: 1030-1048, 2016 pubmed

  • Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T

    Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study.

    Diabetes Care  39: 1543-1549, 2016 pubmed

  • Qiu M, Sato S, Zheng D, Wang X, Carcel C, Hirakawa Y, Sandset EC, Delcourt C, Arima H, Wang J, Chalmers J, Anderson CS; INTERACT Investigators

    Admission heart rate predicts poor outcomes in acute intracerebral hemorrhage: the intensive blood pressure reduction in acute cerebral hemorrhage trial studies.

    Stroke  47: 1479-1485, 2016 pubmed

  • Hirakawa Y, Arima H, Webster R, Zoungas S, Li Q, Harrap S, Lisheng L, Hamet P, Mancia G, Poulter N, Neal B, Williams B, Rogers A, Woodward M, Chalmers J

    Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes.

    J Hypertens  34: 781-787, 2016 pubmed

  • Tanaka S, Ninomiya T, Taniguchi M, Fujisaki K, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K

    Comparison of oral versus intravenous vitamin D receptor activator in reducing infection-related mortality in hemodialysis patients: the Q-Cohort Study.

    Nephrol Dial Transplant  31: 1152-1160, 2016 pubmed

  • NCD Risk Factor Collaboration (NCD-RisC) (Hata J, Ninomiya T)

    Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

    Lancet  387: 1513-1530, 2016 pubmed

  • Xie X, Liu Y, Perkovic V, Li X, Ninomiya T, Hou W, Zhao N, Liu L, Lv J, Zhang H, Wang H

    Renin-angiotensin system inhibitors and kidney and cardiovascular outcomes in patients with CKD: a bayesian network meta-analysis of randomized clinical trials.

    Am J Kidney Dis 67: 728-741, 2016 pubmed

  • Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, Chalmers J, Mant J, Salam A, Rahimi K, Perkovic V, Rodgers A

    Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.

    Lancet 387: 435-443, 2016 pubmed

  • Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study.

    BMC Psychiatry  16: 215, 2016 pubmed

  • Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Tsuzaki K, Takahashi K, Kuzuya H; Japan Diabetes Prevention Program (JDPP) Research Group

    Effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance related to beta-3 adrenergic receptor gene polymorphism Trp64Arg(C/T): results from the Japan Diabetes Prevention Program.

    J Diabetes Investig  7: 338-342, 2016 pubmed

  • NCD Risk Factor Collaboration (NCD-RisC) (Kiyohara Y, Ninomiya T)

    Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants.

    Lancet  387: 1377-1396, 2016 pubmed

  • Honda H, Sasaki K, Hamasaki H, Shijo M, Koyama S, Ohara T, Ninomiya T, Kiyohara Y, Suzuki SO, Iwaki T

    Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama Study.

    Neuropathology  36: 383-387, 2016 pubmed

  • Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, Matsumoto T, Matsui T, Tanaka H, Motoya S, Suzuki Y, Kiyohara Y, Kitazono T, Kubo M

    Genetic characteristics of inflammatory bowel disease in a Japanese population.

    J Gastroenterol  51: 672-681, 2016 pubmed

  • Nagai M, Ohkubo T, Miura K, Fujiyoshi A, Okuda N, Hayakawa T, Yoshita K, Arai Y, Nakagawa H, Nakamura K, Miyagawa N, Takashima N, Kadota A, Murakami Y, Nakamura Y, Abbott RD, Okamura T, Okayama A, Ueshima H; NIPPON DATA80 Research Group (Kiyohara Y)

    Association of total energy intake with 29-year mortality in the Japanese: NIPPON DATA80.

    J Atheroscler Thromb  23: 339-354, 2016 pubmed

  • Hashimoto S, Yasuda M, Ninomiya T, Hata J, Yoshida D, Tahara-Asakuma T, Hirakawa Y, Arakawa S, Fujiwara K, Kiyohara Y, Ishibashi T

    Foveal and macular thickness in a Japanese population: the Hisayama Study.

    Ophthalmic Epidemiol  23: 202-208, 2016 pubmed

  • Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    Serum uric acid as a risk factor for chronic kidney disease in a Japanese community - the Hisayama Study -.

    Circ J  80: 1857-1862, 2016 pubmed

  • Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T

    Serum angiopoietin-like protein 2 is a novel risk factor for cardiovascular disease in the community: the Hisayama Study.

    Arterioscler Thromb Vasc Biol  36: 1686-1691, 2016 pubmed

  • Okayama A, Okuda N, Miura K, Okamura T, Hayakawa T, Akasaka H, Ohnishi H, Saitoh S, Arai Y, Kiyohara Y, Takashima N, Yoshita K, Fujiyoshi A, Zaid M, Ohkubo T, Ueshima H; NIPPON DATA80 Research Group

    Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study.

    BMJ Open  6: e011632, 2016 pubmed

  • Fukuyama S, Matsumoto K, Kaneko Y, Kan-O K, Noda N, Tajiri-Asai Y, Nakano T, Ishii Y, Kiyohara Y, Nakanishi Y, Inoue H; Hisayama Pulmonary Physiology Study Group

    Prevalence of airflow limitation defined by pre- and post-bronchodilator spirometry in a community-based health checkup: the Hisayama Study.

    Tohoku J Exp Med  238: 179-184, 2016 pubmed

  • Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A

    Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols.

    PLoS One  11: e0147519, 2016 pubmed

  • Chatterjee S, Peters SA, Woodward M, Mejia Arango S, Batty GD, Beckett N, Beiser A, Borenstein AR, Crane PK, Haan M, Hassing LB, Hayden KM, Kiyohara Y, Larson EB, Li CY, Ninomiya T, Ohara T, Peters R, Russ TC, Seshadri S, Strand BH, Walker R, Xu W, Huxley RR

    Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia.

    Diabetes Care  39: 300-307, 2016 pubmed

  • Umemoto S, Ogihara T, Matsuzaki M, Rakugi H, Ohashi Y, Saruta T; Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial Group (Kiyohara Y)

    Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial.

    Hypertens Res  39: 46-53, 2016 pubmed

  • Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y

    The long-term association between physical activity and risk of dementia in the community: the Hisayama Study.

    Eur J Epidemiol  31: 267-274, 2016 pubmed

  • Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y

    Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study.

    Sci Rep  6: 22164, 2016 pubmed

九州大学大学院 医学研究院





九州大学大学院 医学研究院


〒812-8582 福岡市東区馬出3-1-1
TEL:092-642-6151 FAX:092-642-4854 Mail:info_eph@hisayamalife.or.jp